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A systematic review of the neurologic literature identified 433 cases of pathologically proven multiple system atrophy over a 100 year period.There were no differences in survival according to gender,parkinsonian,or pyramidal features or whether the patient was classified as striatonigral degeneration or olivopontocerebellar atrophy type.These results demonstrate the poor prognosis for patients with multiple system atrophy but may be biased toward the worse cases.Future research needs to recruit more representative samples. |
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